Epidermal Permeability Barrier Defects and Barrier Repair Therapy in Atopic Dermatitis
نویسندگان
چکیده
منابع مشابه
Epidermal Permeability Barrier Defects and Barrier Repair Therapy in Atopic Dermatitis
Atopic dermatitis (AD) is a multifactorial inflammatory skin disease perpetuated by gene-environmental interactions and which is characterized by genetic barrier defects and allergic inflammation. Recent studies demonstrate an important role for the epidermal permeability barrier in AD that is closely related to chronic immune activation in the skin during systemic allergic reactions. Moreover,...
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Atopic dermatitis (AD) is a complex disease that affects up to 20% of children and impacts the quality of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Filaggrin (FLG) is synthesized as a large precursor, profilaggrin, and is expressed in the u...
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of the epidermal barrier has expanded greatly over the course of the last two decades. Primary functions of the epidermal barrier are to protect against the entry of foreign substances (antigens, irritants, and microbes). In addition to these primarily defensive roles, the epidermis traps moisture and regulates hydration, and it synthesizes vitamin D. The epidermal barrier is not a passive stru...
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The skin represents the largest organ of the body and provides a vital interface between the body and the environment. Hereditary and acquired alterations of structural proteins and lipids of the stratum corneum and epidermal tight junctions leading to a diminished skin barrier function are major causative factors for a number of skin diseases, in particular atopic dermatitis (AD). This review ...
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ژورنال
عنوان ژورنال: Allergy, Asthma & Immunology Research
سال: 2014
ISSN: 2092-7355,2092-7363
DOI: 10.4168/aair.2014.6.4.276